FGF Signaling and Early Lung Development Essay -- Biology, Lung

Epithelial-mesenchymal interactions mediate organogenesis, which results from the activation of coordination compound gene networks. Early respiratory victimization arises from the foregut endoderm and gives rise to tracheal and lung progenitor cells. Recent studies have linked fibroblast growth component part, Wnt, and other(a)(a) mansion pathways to the initial stages of lung development. Cells respond to foretoken proteins mainly though transcription factors that in the long run determine cell fate and pattern habitusation. Gain and loss-of-function studies have facilitated the realization and functionality of molecular components as part of development. Fibroblast growth factor (FGF) signaling plays an central role in the regulatory network present in immature pulmonary development. FGF controls cell proliferation, differentiation and pattern formation however, the interaction of FGF with other signaling pathways is still questioned by researchers. FGF-7 and FGF-10 are important for patterning and growth of the lung bud and are differentially regulated by FGF-1 and FGF-2. Research has shown FGF is an important factor in respiratory development as it regulates the conceptualization of other signaling pathways. Said molecular events involving FGF signaling drive key phases of pulmonary development and thus the understanding of these key segmental mechanicss gives way to new familiarity of pathogenesis involving congenital anomalies, helping to develop innovative therapies to treat disease. Unless specifically mentioned, anything regarding expression patterns and developmental effects of morphogens, transcription and growth factors, or any other developmental factors effecting lung development are referenced from the murine lung. Accordingly, functional relevance... ...change, an super complicated process. The lung is an organ that contains a vast system of airways carefully constructed to gain maximal surface area in a confined space. Thi s helps to form an environment suitable for the bronchial and pulmonary vascular systems. These airways that grow come in into the body, like a tree towards the sky, require careful guidance from numerous developmental factors such as transcriptional regulators, growth factors, morphogens and extra cellular hyaloplasm molecules. When mutations in the genes that control these factors occur, aberrations during lung development can arise and may go along to severe morbidity or mortality at birth delinquent to respiratory failure. The FGF signaling pathway is one such signaling mechanism that is critical to proper lung formation, guiding branching morphogenesis and cellular proliferation of the developing lung.